Pharmacists can play a critical role in the care of persons living with human immunodeficiency virus (HIV). This activity will provide an overview of the medications used in the treatment of HIV. Specifically, discussed will be the different classes of antiretrovirals, including the mechanism of action, common side effects, drug-drug interactions, and limitations or special considerations which are unique to specific agents. Also described are the current treatment recommendations for initiating HIV drug therapy with antiretrovirals. Additionally, we will review Florida law as it pertains to HIV testing, including partner notification, privilege to warn, and testing in pregnant women.